EndoPelvic - Centro Multidisciplinar de Endometriose
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Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis



To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.


Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.


Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).


Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.

Keywords: statin, GnRHa, endometriosis, chronic pelvic pain, dysmenorrhea, dyspareunia