Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis
Abstract
Background
To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
Material/Methods
Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
Results
Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
Conclusions
Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.
Keywords: statin, GnRHa, endometriosis, chronic pelvic pain, dysmenorrhea, dyspareunia
